Supernatural casts another one of the Four Horseman of the Apocalypse, Pestilence. According to TV Guide Magazine, the series "is searching for a 40-50 year old man to play Pestilence. This latest Horseman is described as quirky, unassuming and highly intelligent."
Supernatural also casts Tyson, a character from Sam's Stanford years. He works for a pharmaceutical company, "and has plans to capitalize on a disgusting flu virus by providing the vaccine."
Source: TV Guide Magazine.