Supernatural: Jensen Ackles and Jared Padalecki Talk Season 6

"Supernatural returns this Friday, in a season that follows what happens to Sam and Dean now that they've fought angels, demons and the Devil himself. The producers have said this season is returning to stories of monsters and creatures, but also focuses on where these old school foes actually come from for this first time. At the same time, the Winchester brothers also deal with Sam's trip to hell and back and Dean's time living a very different, domesticated existence while Sam was gone."

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