SCI FI Wire listed 68 must-see sci-fi sights around the U.S., listing Vancouver, British Columbia as one:
"Not only is this part of the country absolutely breathtaking in its natural beauty, but Vancouver has been the filming location of countless science fiction series and movies, including Battlestar Galactica, Smallville, Supernatural, Dark Angel, New Moon, Andromeda, Alien vs. Predator, Stephen King's It, The Fog, Stargate Atlantis and The X-Files. (And yes, we know Vancouver isn't in the U.S., but since it's within striking distance, we decided to list it anyway.)"
Source: SCI FI Wire.