According to EW.com's Michael Ausiello, Supernatural creator Eric Kripke maintains that as the series is in its fifth season, he has "every intention of ending the story with a bang and not drawing it out or watering it down."
That said, Kripke added that he is "looking at this season as the last chapter in this particular story. That doesn’t mean there can’t be a new story. Buffy did it. The X-Files did it. You close a chapter on a big mythology storyline and then you begin a new one."
Ausiello mentions that the CW has yet to renew Supernatural for a sixth season, and that even if it does, Kripke doesn’t have a deal in place beyond season 5.
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Source: EW.com.