Spoilers alert!
Click here for E! Online Kristin Dos Santos Comic-Con Q&A with Jensen Ackles, Jared Padalecki and Supernatural creator Eric Kripke, and here for MovieWeb video interviews with Ackles, Kripke and Supernatural writer and producer Sera Gamble.
And SF Universe has a Supernatural interview with Jensen Ackles, including audio clip.
For more reports, videos and photos from Supernatural panel check Supernatural-wiki, here.